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Studies showed 100% sterility in mice after dosing, which was found to be fully reversible after drug discontinuation.

It is designed to be a "male pill" that targets only the necessary receptor, aimed at reducing side effects found in older, less specific studies (like those using BMS-189453). Male.rar

pathway, which is essential for spermatogenesis (sperm production). By blocking this receptor, the drug prevents sperm production without using hormones. Studies showed 100% sterility in mice after dosing,

YCT-529 is an experimental, non-hormonal male contraceptive developed by YourChoice Therapeutics. It acts as a selective inhibitor of the retinoic acid receptor alpha (RAR- Mechanism of Action: It functions by targeting the RAR- By blocking this receptor, the drug prevents sperm

Based on your search request, here is the relevant review information for in the context of recent developments for a potential new product, focusing on the YCT-529 molecule, as of April 2026: