Villarreal ultimately dominated Group C, finishing first with 13 points, while Hapoel Be'er Sheva finished third, failing to advance to the knockout stages. These matches are remembered as a resilient effort by the Israeli side against a seasoned Spanish powerhouse that had recently won the Europa League.
: Álex Baena secured a 1–2 victory for the "Yellow Submarine" with a strike in the 67th minute, assisted by Yéremy Pino. Match 2: A High-Scoring Draw in Spain Villarreal vs Hapoel Be'er
: Tomer Hemed put the visitors ahead in the 48th minute after a handball by Aïssa Mandi led to a penalty. Match 2: A High-Scoring Draw in Spain :
: Samuel Chukwueze equalized in the 57th minute, followed by an Arnaut Danjuma goal in the 70th minute to give Villarreal the lead. : José Luis Morales opened the scoring in
On September 15, 2022, Villarreal traveled to Israel for a demanding midweek fixture.
: José Luis Morales opened the scoring in the 28th minute with a penalty earned by Álex Baena.