Resting at the Inn can trigger new quirks. If a character receives a "character-breaking" negative quirk at the Last Inn, there is often no subsequent Field Hospital to remove it.
Reaching and utilizing the Last Inn carries specific "roguelite" risks: The Last Inn
If a run is deemed untenable, "Ending the Expedition" at the Last Inn allows players to retain 100% of collected Hope (Candles), whereas dying in the final zone may result in loss. Resting at the Inn can trigger new quirks
Manual save before inn rest to prevent pawn issues - Facebook The Last Inn
Ensure every hero has a full stack of offensive or curative items.