: Note that PCRMP4 is distinct from pCRMP4 (phosphorylated Collapsin Response Mediator Protein 4), a human protein involved in axonal growth, spinal cord injury response, and certain cancers like pancreatic cancer.
: Parasites lacking PCRMP4 fail to invade the mosquito's salivary glands, preventing them from being transmitted to a host during a mosquito bite. pcrmp4
: PCRMP4 is not required for the parasite's survival during the blood-stage of infection (the stage that causes symptoms in humans), but it is absolutely necessary for completing the complex life cycle through the mosquito. Research and Medical Context : Note that PCRMP4 is distinct from pCRMP4
PCRMP4 is essential for the transmission of malaria. Its primary known functions include: spinal cord injury response