This forced "metabolic shift" encourages cells to use alternative fuel sources like ketones and fatty acids through -oxidation.
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MSDC-0160 works by selectively binding to and inhibiting the , a protein complex in the inner mitochondrial membrane. This forced "metabolic shift" encourages cells to use
MSDC-0160 is a novel, clinical-stage drug candidate originally developed for . It is the prototype of a new class of insulin sensitizers called mTOT Modulators (Mitochondrial Target of Thiazolidinediones). Unlike first-generation insulin sensitizers like pioglitazone, MSDC-0160 is PPAR Research has expanded beyond diabetes to several age-related
In preclinical models, MSDC-0160 protected dopaminergic neurons, improved motor function, and reduced neuroinflammation.
Research has expanded beyond diabetes to several age-related and neurodegenerative conditions: 1. Parkinson’s Disease (PD)