The name is an acronym for the four independent predictors it tracks:
The model categorizes patients into three risk groups based on how many of these four parameters they meet: Risk Subgroup Criteria (Parameters met) Progression-Free Survival (PFS) Overall Survival (OS) 0 parameters Intermediate 1 or 2 parameters High-Risk 3 or more parameters
💡 The inclusion of the P4 (Interim PET) parameter is significant because it allows doctors to adjust treatment mid-course based on how the tumor is actually responding to chemotherapy. Clinical Significance The name is an acronym for the four
Changes in interim PET/CT scan results after 4 treatment cycles (specifically a decrease in SUVmax < 71%). Risk Stratification & Survival Rates
Documented meningeal lymphomatosis (spread to the brain or spinal cord membranes). Research indicates that variables like bulky disease and
If you are looking for or comparisons to other models like the IPI or NCCN-IPI , I can provide those details.
Research indicates that variables like bulky disease and Ki67 are strong independent predictors of how long a patient will remain in remission. I can provide those details.
While the International Prognostic Index (IPI) is the standard, KBMP4 provides a more granular look at aggressive "Double-Hit" or "Double-Expression" lymphomas.