The episode also deals with the fallout of House lying to Cuddy in a previous case, causing significant tension in their new romantic relationship. "House" A Pox on Our House (TV Episode 2010) - IMDb

This episode prominently features medical student Martha Masters, whose research into the shipwreck's history—specifically the death of a ship's cat—leads to the correct diagnosis.

A teenage girl is admitted to Princeton-Plainsboro after a 200-year-old glass jar from a shipwreck shatters in her hand. When she begins showing symptoms of smallpox , a disease eradicated decades ago, the hospital is put under lockdown by the CDC.