Gd2.zip Site

Chimeric or humanized antibodies like Dinutuximab and Naxitamab are FDA-approved for high-risk neuroblastoma. They work by triggering immune-mediated cell death (ADCC and CDC).

GD2 is considered an ideal target for precision medicine because of its high density on certain tumor cells. gd2.zip

It is synthesized in the Golgi apparatus from precursors like GM3 and GD3. Key enzymes in this pathway include ST8SIA1 (GD3 synthase) and B4GALNT1 (GD2 synthase). gd2.zip