G9048.mp4 【FAST ✧】

Based on the full text of the study, supplemental videos (often named with similar codes) typically demonstrate:

: Time-lapse footage of cancer cells moving across substrates of varying stiffness. g9048.mp4

: Observations of "leader cells" responding to GLI2 inhibition. Based on the full text of the study,

: This signaling activates fibroblasts, which increase tissue stiffness by producing collagen. g9048.mp4

The research, published in journals such as and archived on PMC , explores how tissue stiffness and biochemical signaling work together to drive cancer growth. Key Research Findings

: Injured epithelial cells release Sonic Hedgehog (SHH) ligands.

: The resulting stiffened tissue triggers non-canonical activation of the transcription factor GLI2 in epithelial cells.