: Under normal conditions, MICA is rarely expressed on healthy cells. However, it becomes highly expressed when cells undergo viral infection, malignant transformation (cancer), or heat shock [2, 3].
The MICA gene encodes a cell surface glycoprotein that acts as a "distress signal." Dnaddr.Mica_P-1-10.1.var
: Some tumors have evolved to "shed" MICA from their surface. By releasing these proteins into the bloodstream, the cancer cells can "blind" the immune system’s NK cells, allowing the tumor to grow undetected [3, 8]. : Under normal conditions, MICA is rarely expressed