The solute must not undergo association (clumping) or dissociation (breaking into ions) in either solvent. If the solute reacts with a solvent or ionizes, the formula must be modified to account for these chemical changes. Practical Applications
are the equilibrium concentrations of the solute in Solvent 1 and Solvent 2. KDcap K sub cap D is the Distribution Coefficient (or Partition Coefficient). Necessary Conditions and Limitations distribution law
If the distribution coefficient and the solubility of a solute in one solvent are known, its solubility in the second solvent can be calculated. The solute must not undergo association (clumping) or
Solubility is temperature-dependent; therefore, KDcap K sub cap D only remains constant if the temperature is stable. where the solute behaves ideally.
The law is most accurate at low concentrations, where the solute behaves ideally.