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: Targeting the Oxidative Activation of Protein Kinase G Iα: A Novel Therapeutic Approach for Hypertension.

: Use of C57BL/6 mice and specialized Cys42Ser KI (knock-in) mice that are resistant to PKG oxidative activation. 23484.rar

: Show that mice unable to form the PKG disulfide bond (C42S KI) exhibit different blood pressure responses compared to wild-type (WT) mice. : Targeting the Oxidative Activation of Protein Kinase

: This identifies a "drugable" target that is distinct from the nitric oxide/cGMP pathway. 23484.rar